External Business Environment Assignment Example | Topics and Well Written Essays - 3500 words

External Business Environment - Assignment Example The industries dominating the UK economy include the service sector, the automotive sector, and the pharmaceutical industry. The service sector, in particular, contributes more than three-quarters of the country’s GDP, with the booming services within the industry being the financial and aerospace. Being the first county to adopt industrialization, the country boasts of one of the largest globalized economies of the world, and the city of London plays an instrumental role as the business hub for this economic giant. The UK is part of the G8, which is a group of some of the leading economies in the world in terms of economic strength and power. The UK has an elaborate tax system that promotes both internal and foreign investments within the country. So far, the UK boats of being the leader in the following industries across the world, owing to its policies and attractive strategies geared at enticing investors within the country. One, London City is the Hub of financial services in the world, owing to the elaborate banking system adopted by the country, and evidenced by some of the leading multination banking corporations in the world such as the Barclays Bank, and the Standard Chartered Bank. Second, is the Barclays Premier League, adopted after the main sponsor, Barclays Bank, which is the most followed football league in the entire globe. The UK always comes up with economic policies that promote business activities and investments within the country. The hospitality industry plays a major role in the UK economy as it contributes almost 25% of the GDP of the country, comprising of companies such as clubs, hotels, restaurants, leisure outlets and holiday resorts. The Intercontinental Hotels and Resorts is one of the major hotel groups in the UK, with an international disposition of its chains of hotels and resorts across various countries and cities of the world. As such, as a leading hotel group in the United Kingdom, the economic policies set by the government affect its operations adversely, either positively or negatively.  Ã‚  

Case Study Discuss the pathpyysiology of Myelofibrosis Essay

Case Study Discuss the pathpyysiology of Myelofibrosis - Essay Example This disease is characterized by fibrosis and sclerosis of bone marrow. To compensate for the hematopoietic cell population, extramedullary hematopoiesis takes place in the spleen, accounting for the massive enlargement of the spleen. This disease occurs predominantly in subjects over the age of 54 years. The bone marrow fibrosis is the hallmark of pathological findings in such cases, where extensive fibrosis with resultant peripheral blood leukoerythroblastosis is expected as a typical histopathologic picture on bone marrow biopsy (Tefferi, 2000, p. 1255-1265). This clinically heterogeneous group of diseases stems from clonal proliferation of stem cell origin and is characterized at least initially by marrow hypercellularity with varying degrees of marrow fibrosis and an increase in the production of one or more terminally differentiated cell types. These differentiated elements may accumulate in the bone marrow, in the peripheral blood, and in other organs, such as, spleen. All these diseases demonstrate a variable tendency to undergo disease progression that may terminate in bone marrow failure or in transformation to an acute phase malignant disease. The evaluation of bone marrow histology holds an important role in defining the pathology of this disease, by mainly ruling out unsuspected pathology. The pathologic changes are subtle until the disease has progressed, and therefore, classification of these disorders benefits from the integration of the morphologic features with clinical, hematologic, and cytogenetic findings. Of major impo rtance is the presence or absence of Philadelphia chromosomes (BCR/ABL or translocation9;22). This group of diseases constitutes the classical group of BCR/ABL-negative chronic myeloproliferative disorders. The disease is regarded as one of the chronic myeloproliferative disorders. Recently considerable progress has been made in understanding its pathogenesis, although this has yet to result in significant therapeutic advances. Indeed, its prognosis remains poor when compared to other BCR-ABL-negative chronic myeloproliferative disorders with death resulting from cardiac failure, infection, hemorrhage, and leukemic transformation (Barosi, 2003, p. 1211-1226). Hemapoetic Components It has been appreciated for many years that MF is a clonal disorder and that the disease arises from the proliferation of malignant pluripotential stem cells. Recently, using fluorescent in situ hybridization (FISH), there is evidence that both B and T cells can be involved, while karyotypic analysis has shown that the stromal proliferation is polyclonal, or reactive, and not part of the underlying clonal hematopoiesis. An increased number of circulating hematopoietic precursors, including pluripotent and lineage restricted progenitor cells is a feature of MF and is likely to result from the proteolytic release of stem cells from the marrow. It is also possible that the spleen and liver contribute to the circulating progenitor pool as splenectomy temporarily normalizes levels. The high level of circulating progenitor cells is reflected in the significantly increased peripheral